Research Article
CTLA-4 Gene Polymorphism and the Risk of Systemic Lupus Erythematosus in the Chinese Population
Table 1
Genotypic distribution and allelic frequencies of −1722 CTLA-4 polymorphisms in Chinese SLE patients and healthy controls.
| | Promoter −1722 | SLE
| Controls
| | value | OR (95% CI) |
| | Genotype frequency | | | | | | | TT | 42 (28.4%) | 29 (17.1%) | 5.846 | 0.016 | 1.926 (1.127–3.293) | | TC | 87 (58.8%) | 80 (47.1%) | 4.362 | 0.037 | 1.605 (1.028–2.503) | | CC | 19 (12.8%) | 61 (35.8%) | 22.315 | | 0.263 (0.148–0.468) | | Allele frequency | | | | | | | T | 171 (57.8%) | 138 (40.6%) | 18.701 | | 2.002 (1.459–2.747) | | C | 125 (42.2%) | 202 (59.4%) | | | | | Phenotype | | | | | | | T | 129 (87.2%) | 109 (64.1%) | 6.182 | 0.013 | 1.574 (1.100–2.253) | | C | 106 (71.6%) | 141 (82.9%) | | | |
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Abbreviations: CTLA-4 = cytotoxic T-lymphocyte antigen 4; SLE =systemic lupus erythematosus; OR = odds ratios; 95% CI = 95% confidence interval.
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