Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications
Figure 2
(a) A male canine with X-linked muscular dystrophy (CXMDJ) at 6 months of age. The atrophy of muscles throughout the body (including temporal muscle) is observed. Kyphosis, abnormal sitting posture, and contracture of hindlimb joints are seen. (b) The pathology (H and E) of tibialis cranialis muscle indicates muscle necrosis with infiltration of inflammatory cells, centrally nucleated fibers, and increased interstitial connective tissues.
