Table 2: Major HDAC inhibitors: Targets and current status in cancer chemotherapy.


Aliphatic acidValproic acidClass I, IIaPhase II clinical trials [62]
BenzamideMGCD0103Class I, IIPhase II clinical trials[63]
Cyclic peptideFK228Class I, IIFDA approved for CTCL[64]
HydroxamatesSAHAClass I, IIFDA approved for CTCL[63]
LBH589Class I, IIPhase II and III clinical trials [23]
Trichostatin AClass I, IIExperimental use [65, 66]
OthersAR-42Class I, IIStarted clinical trials [67]
CUDC101Class I, IIStarted clinical trials [68]

Note: Valproic acid has been in use as an anticonvulsant and mood stabilizing drug in the treatment of epilepsy and bipolar disorder.