Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors

Table 2

Major HDAC inhibitors: Targets and current status in cancer chemotherapy.

Class	Compounds	HDACs	Status	Reference
Aliphatic acid	Valproic acid	Class I, IIa	Phase II clinical trials	[62]
Benzamide	MGCD0103	Class I, II	Phase II clinical trials	[63]
Cyclic peptide	FK228	Class I, II	FDA approved for CTCL	[64]
Hydroxamates	SAHA	Class I, II	FDA approved for CTCL	[63]
	LBH589	Class I, II	Phase II and III clinical trials	[23]
	Trichostatin A	Class I, II	Experimental use	[65, 66]
Others	AR-42	Class I, II	Started clinical trials	[67]
	CUDC101	Class I, II	Started clinical trials	[68]

Note: Valproic acid has been in use as an anticonvulsant and mood stabilizing drug in the treatment of epilepsy and bipolar disorder.