The Structural Basis of Ligand Recognition by Natural Killer Cell Receptors

Figure 3

Structure of activating KIR receptors. (a) KIR2DS2 shown in cartoon representation with residues likely important for ligand binding and also the hinge region residues shown in ball and stick representation. (b) Charged surface representation of the membrane distal face (binding face) of KIR2DS2. (c) KIR2DS4 shown in cartoon representation with ligand binding and hinge region residues shown in ball and stick representation. (d) Charged surface representation of the membrane distal face (binding face) of KIR2DS4. (e) For comparative purposes, the inhibitory receptor KIR2DL2 is shown in cartoon representation with ligand binding and hinge region residues shown in ball and stick representation. (f) Charged surface representation of the membrane distal face (binding face) of the inhibitory receptor KIR2DL2.