The Structural Basis of Ligand Recognition by Natural Killer Cell Receptors

Figure 8

Structure of NKG2D homodimer and associated complexes. (a) NKG2D homodimeric structure. (b) NKG2D in the same orientation as (a) in complex with the two domain MICA molecule. (c) NKG2D in complex with ULBP3. (d) MICA structure rotated 90° in orientation relative to (b); residues forming hydrogen bonds with NKG2D are shown in ball and stick representation with red carbon and blue nitrogen atoms while residues forming hydrophobic interactions are shown in yellow transparent surface representation. (e) NKG2D structure rotated 90° in orientation relative to (b); residues forming hydrogen bonds with MICA are shown in ball and stick representation with red carbon and blue nitrogen atoms while residues forming hydrophobic interactions are shown in green transparent surface representation. (f) ULBP3 structure rotated 90° in orientation relative to (c); residues forming hydrogen bonds with NKG2D are shown in ball and stick representation with red carbon and blue nitrogen atoms while residues forming hydrophobic interactions are shown in yellow transparent surface representation. (g) NKG2D structure rotated 90° in orientation relative to (b); residues forming hydrogen bonds with ULBP3 are shown in ball and stick representation with red carbon and blue nitrogen atoms while residues forming hydrophobic interactions are shown in green transparent surface representation.