Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

Table 3

Mean frequency of MLL translocations and extra signals obtained for ALL survivors and healthy individuals (taken from [19]).

Groups of individuals	𝑛	Translocations % (mean±SD)	Extra Signals % (mean±SD)
Patients Treated with topoisomerase II inhibitors	15	0.13±0.14^∗	0.28±0.28
Patients Treated without topoisomerase II inhibitors	31	0.09±0.117^∗	0.16±0.168
Healthy individuals	49	0.04±0.065	0.18±0.198

∗Statistically different, 𝑃<.05.