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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 245821, 6 pages
Review Article

The Application of SELDI-TOF-MS in Clinical Diagnosis of Cancers

Department of Laboratory Medicine, The Affiliated Taizhou Municipal Hospital, Taizhou Medical College, Taizhou 318000, Zhejiang Province, China

Received 20 December 2010; Accepted 30 March 2011

Academic Editor: Vincent C. O. Njar

Copyright © 2011 Chibo Liu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cancer diagnosis is important, and the early diagnosis of cancers could predict a more successful treatment. The proteomic studies emerged to be useful in combined analyses of samples from patients and provide more accurate diagnosis when compared to the single-factor-based diagnosis. In recent years, cancer detection with surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS) is flourishing and brought significant progress in this area. This paper summarizes some recent results with this technique for cancer diagnosis.