Using Rhodamine 123 Accumulation in CD<sup>8+</sup> Cells as a Surrogate Indicator to Study the P-Glycoprotein Modulating Effect of Cepharanthine Hydrochloride In Vivo

<table>Accumulation of Rho123 in CD8<sup>+</sup> cells by different doses of reversors with or without Rho123 at a dose of 2.5 mg/kg <i>in vivo</i>. The increase of the mean fluorescence intensity that reflects the efflux is inhibited. <svg height="13.95" id="M10" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 69.150002 13.95" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, different from the control. The results are the mean ± SD of at least 4 independent experiments.</table>

BioMed Research International

fig3

Figure 3

Figure 3: Using Rhodamine 123 Accumulation in CD<sup>8+</sup> Cells as a Surrogate Indicator to Study the P-Glycoprotein Modulating Effect of Cepharanthine Hydrochloride In Vivo 

Figure 3 | Using Rhodamine 123 Accumulation in CD8+ Cells as a Surrogate Indicator to Study the P-Glycoprotein Modulating Effect of Cepharanthine Hydrochloride In Vivo 