Robust Design of Biological Circuits: Evolutionary Systems Biology Approach

Figure 9

Simulation of biological repressilator: (a) TetR; (b) CI; (c) LacI. In contrast to the above design case, the design parameters are specified aside the best fit parameter 𝑘^∗, for example, with 𝑘₁=1.5, 𝑘₂=1.9, 𝑘₃=1.2, 𝑘₄=0.79, 𝑘₅=1.1, and 𝑘₆=0.96. In this design case, the mean errors 𝑒 are 0.91, 1.36, and 1.18 with standard deviations of 0.29, 0.35, and 0.27 for TetR, CI, and LacI, respectively.

(a)

(b)

(c)