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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 307297, 4 pages
http://dx.doi.org/10.1155/2011/307297
Review Article

Microarray Analysis for a Comprehensive Immunological-Status Evaluation during Cancer Vaccine Immune Monitoring

Vladia Monsurrò1,2 and Francesco M. Marincola3

1Department of Pathology and Diagnostic, University of Verona Medical School, Verona, Italy
2Azienda Ospedaliera Universitaria Integrata, Verona, Italy
3Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

Received 1 July 2011; Accepted 5 August 2011

Academic Editor: Yongqun O. He

Copyright © 2011 Vladia Monsurrò and Francesco M. Marincola. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. P. Peethambaram, M. E. Melisko, K. J. Rinn et al., “A phase I trial of immunotherapy with lapuleucel-T (APC8024) in patients with refractory metastatic tumors that express HER-2/neu,” Clinical Cancer Research, vol. 15, no. 18, pp. 5937–5944, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. V. Monsurrò, D. Nagorsen, E. Wang et al., “Functional heterogeneity of vaccine-induced CD8+ T cells,” Journal of Immunology, vol. 168, no. 11, pp. 5933–5942, 2002. View at Google Scholar · View at Scopus
  3. M. B. Nielsen, V. Monsurro, S. A. Migueles et al., “Status of activation of circulating vaccine-elicited CD8+ T cells,” Journal of Immunology, vol. 165, no. 4, pp. 2287–2296, 2000. View at Google Scholar · View at Scopus
  4. S. Seiter, V. Monsurro, M. B. Nielsen et al., “Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes,” Journal of Immunotherapy, vol. 25, no. 3, pp. 252–263, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Monsurrò, M. B. Nielsen, A. Perez-Diez et al., “Kinetics of TCR use in response to repeated epitope-specific immunization,” Journal of Immunology, vol. 166, no. 9, pp. 5817–5825, 2001. View at Google Scholar · View at Scopus
  6. V. Monsurrò, E. Wang, Y. Yamano et al., “Quiescent phenotype of tumor-specific CD8+ T cells following immunization,” Blood, vol. 104, no. 7, pp. 1970–1978, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. V. Monsurrò, E. Wang, M. C. Panelli et al., “Active-specific immunization against melanoma: is the problem at the receiving end?” Seminars in Cancer Biology, vol. 13, no. 6, pp. 473–480, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. S. A. Rosenberg, J. C. Yang, and N. P. Restifo, “Cancer immunotherapy: moving beyond current vaccines,” Nature Medicine, vol. 10, no. 9, pp. 909–915, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. V. Monsurrò and F. M. Marincola, “Gene profiling for the prediction of tumor response to treatment: the case of immunotherapy,” Advances in Experimental Medicine and Biology, vol. 593, pp. 86–94, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. C. Ma, R. Fan, H. Ahmad et al., “A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells,” Nature Medicine, vol. 17, no. 6, pp. 738–743, 2011. View at Publisher · View at Google Scholar · View at PubMed
  11. J. M. Zimmerer, G. B. Lesinski, A. S. Ruppert et al., “Gene expression profiling reveals similarities between the in vitro and in vivo responses of immune effector cells to IFN-α,” Clinical Cancer Research, vol. 14, no. 18, pp. 5900–5906, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. E. Aricò, L. Castiello, F. Urbani et al., “Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments,” Journal of Translational Medicine, vol. 9 article 67, 2011. View at Publisher · View at Google Scholar · View at PubMed
  13. A. Worschech, N. Chen, Y. A. Yu et al., “Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy,” BMC Genomics, vol. 10, article 301, 2009. View at Publisher · View at Google Scholar · View at PubMed
  14. M. E. Kohler, W. H. D. Hallett, Q. R. Chen, J. Khan, B. D. Johnson, and R. J. Orentas, “Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine,” Cellular Immunology, vol. 265, no. 1, pp. 65–73, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. E. Wang, “Microarrays Gene expression profiling approaches for the monitoring of anti-cancer immune responses,” in Analyzing T Cell Responses, D. Nagorsen and F. M. Marincola, Eds., pp. 285–301, Springer, Amsterdam, The Netherlands, 2005. View at Google Scholar
  16. R. J. Critchley-Thorne, N. Yan, S. Nacu, J. Weber, S. P. Holmes, and P. P. Lee, “Down-regulation of the interferon signaling pathway in T lymphocytes from patients with metastatic melanoma,” PLoS Medicine, vol. 4, no. 5, pp. 0897–0911, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. K. W. Makar, P. Aaron, and L. A. Jones, “Application of microarray technology to the immune monitoring of therapeutic cancer vaccines,” in Proceedings of the AACR Annual Meeting, Anaheim, Calif, USA, 2005.
  18. S. Thomas and D. Bonchev, “A survey of current software for network analysis in molecular biology,” Human Genomics, vol. 4, no. 5, pp. 353–360, 2010. View at Google Scholar
  19. M. Laakso and S. Hautaniemi, “Integrative platform to translate gene sets to networks,” Bioinformatics, vol. 26, no. 14, Article ID btq277, pp. 1802–1803, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus