| Model | Characteristics | Tumor histology | Tumor location | Incidence of cancer | References |
| IL-2 x β 2-M DKO | UC-like | Carcinoma | Rectum, colon | 32% adenocarcinoma | Sohn et al., 2001 [41] | IL-10 KO | CD-like duodenitis, colitis | Carcinoma | Colon, rectum | 60% adenocarcinoma | Shattuck-Brandt et al., 2000 [42] | RAG2 KO | Induced by infecting with H. hepaticus | Dysplasia, tubular adenoma, carcinoma, adenocarcinoma | Cecum, colon | 100% adenocarcinoma | Erdman et al., 2003 [43] | RAG2/Tgfβ1 DKO | Colitis | Dysplasia, adenocarcinoma | Cecum, colon | 100% adenocarcinoma | Erdman et al., 2003 [43] | TCRβ/p53 DKO | UC-like | Dysplasia, adenocarcinoma | Ileocecum, cecum | 70% adenocarcinoma | Kado et al., 2001 [44] | Gpx1/Gpx2 DKO | Ileocolitis | Dysplasia, adenocarcinoma, signet ring cell carcinoma | Ileum, colon | 28% adenocarcinoma | Chu et al., 2004 [45] | Gαi2 KO | UC-like | Carcinoma | Colon | 31% adenocarcinoma | Rudolph et al., 1995 [46] | Msh2 KO | HNPCC | Adenoma, adenocarcinoma | Jejunum | 38.9% adenocarcinoma | Reitmair et al., 1996 [47] | Msh3 x Msh6 DKO | HNPCC | Adenoma, adenocarcinoma, lymphoma | GI tract | 81.3% adenocarcinoma | Edelmann et al., 2000 [48] | Msh6 KO | HNPCC | Adenoma, adenocarcinoma, lymphoma | GI tract | 38.5% adenocarcinoma | Edelmann et al., 2000 [48] | Mlh1 KO | HNPCC | Adenomas, adenocarcinomas | GI tract | 72.0% tumor incidence 9.36% adenocarcinoma | Edelmann et al., 1999 [49] | Mlh3 KO | HNPCC | Adenomas, adenocarcinomas | GI tract | 52% tumor incidence 14% adenocarcinoma | Chen et al., 2005 [50] | Mlh3 x Pms2 DKO | HNPCC | Adenomas, adenocarcinomas | GI tract | 42% tumor incidence | Chen et al., 2005 [50] | Msh2G674A/G674A | HNPCC | Adenocarcinomas | GI tract | 19% adenocarcinoma | Lin et al., 2004 [51] | MlhG67R/G67R | HNPCC | Adenocarcinoma, adenoma, squamous basal cell carcinoma | GI tract | 61% adenocarcinoma | Avdievich et al., 2008 [52] |
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Abbreviations: CD, Crohn’s disease; DKO, double knockout; GI, gastrointestinal; HNPCC, hereditary nonpolyposis colorectal cancer; KO, knockout; RAG, recombination-activating gene: UC, ulcerative colitis.
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