Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women

Table 2

Detailed list of 18:X chromosome signals found in the patient group.

Case no.	Diagnosis	Age at menopause	Number of signals (18:X)			Other	Total
			2: 1	2:2	2:3
1	POF2-FAM2	45	5	51	5	0	61
2	PA	/	7	54	3	0	64
3	POF1-FAM2	40	11	69	10	0	90
4	POF1	27	6	86	8	0	100
5	POF1	33	13	99	7	0	119
6	POF2	42	16	82	2	0	100
7	POF1-FAM2	36	3	138	9	0	150
8	PA-FAM1	/	12	56	11	20	99
9	POF2-FAM1	41	7	81	3	9	100
10	POF1-FAM2	35	16	72	3	8	99
11	POF1-FAM1	34	12	76	3	8	99
12	POF1	12	10	74	9	8	101
13	POF2	42	17	74	2	11	104
14	POF1-FAM1	33	8	72	3	13	96
15	POF1-FAM1	38	19	62	3	15	99
16	PA	/	15	74	2	9	100
17	POF1	32	5	83	2	11	101
18	POF1	35	11	75	4	10	100
19	POF1	37	10	74	6	9	99
20	POF1-FAM1	25	4	88	6	2	100
21	POF1	40	6	89	1	4	100
22	POF1-FAM1	37	10	76	6	8	100
23	POF1	34	6	32	8	54	100
24	POF1-FAM2	34	4	35	6	5	50
25	POF1	37	6	80	10	4	100
26	POF1-FAM1	18	9	87	4	5	105
27	POF1-FAM1	34	12	176	6	14	208
28	POF1	30	11	167	0	6	184
29	POF1-FAM2	35	16	167	5	12	200
30	POF1	34	13	168	6	7	194
31	POF1	27	9	180	7	3	199
32	POF1	40	14	183	8	2	207
33	POF1	40	6	190	4	3	203
34	POF1-FAM1	40	13	182	4	5	204
35	POF2	41	15	177	5	7	204
36	POF1	26	12	182	4	5	203
37	POF2	44	12	188	2	2	204
38	POF1-FAM2	30	10	187	4	4	205
39	POF1-FAM2	33	4	176	8	14	202
40	PA	/	23	177	2	3	205
41	PA	/	12	192	2	2	208
42	POF1-FAM1	38	12	192	1	4	209
43	POF1	38	13	191	5	5	214
44	POF1-FAM1	18	10	190	2	3	205
45	POF1	38	15	181	6	7	209
46	POF1-FAM1	17	15	185	3	3	206
47	POF1-FAM1/2	31	17	184	4	5	210
%			7.4	84.4	3.3	4.8

POF1: menopause before or at the age of 40; POF2: menopause between 41 and 45 years of age; PA: primary amenorrhea; FAM1: at least one relative with POF1; FAM2: at least one relative with POF2.