Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

Table 1

Mammalian Members of HAT Family.

Mammalian HATs
Class	Subclass	Homology to yeast	Mammalian members	Mechanism of catalysis	Cell localization
A	GNAT-family	Gcn5	GCN5L	Transfer of acetyl group from acetyl-CoA to ε-NH2 group of histone N-tails after the assembly into nucleosomes	Nucleus
			PCAF
			MYST-family			Esa1; Sas2; Sas3	Tip60
	HBOI
	MORF
	MOZ
	CLOCK
	NCOAT
	MOF
	Others	HATI; Elp3; Hpa2; NutI					p300/CBP
			TFIIIC complex
			ACTR/SRC-I
			ATF-2
	B		Hat1			HAT1	Transfer of acetyl group from acetyl-CoA to ε-NH2 group of free histones prior to their deposition on DNA	Cytoplasm