Metabolomics Reveals Relationship between Plasma Inositols and Birth Weight: Possible Markers for Fetal Programming of Type 2 Diabetes
Figure 3
Myo-inositol and D-chiro-inositol levels in plasma from low birth weight (LW) and high birth weight (HW) piglets. (a) GC-MS spectra of a representative plasma sample. Peak at retention time 11.61 is D-chiro-inositol and peak at retention time 12.60 is myo-inositol. The spectra reveal the large difference in concentration of D-chiro-inositol and myo-inositol in the plasma samples. (b) Arbitrary plasma inositol levels in LW and HW piglets, showing that LW piglets have a significantly higher plasma concentration of both myo- and D-chiro-inositol than HW piglets at birth. Each bar represents the LSMeans of 12 piglets SEM. ab, Bars named ratio is representing the ratio between D-chiro-inositol and myo-inositol.
