Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells

Table 1

Changes in cytokine production patterns by murine splenocytes in Th17-skewed conditions by the addition of S. thermophilus ST28 or S. thermophilus ATCC 19258.

Cytokine (pg/mL)	Control		TGF-β + IL-6 (+)
		(−)	S. thermophilus ST28	S. thermophilus ATCC 19258
IL-17	412 ± 17**	4,383 ± 192	976 ± 21^** ##	4,858 ± 116
IFN-γ	616 ± 47**	4,960 ± 105	2,215 ± 369^** ##	564 ± 91**
IL-2	909 ± 325**	102 ± 7	1,311 ± 344^** ##	9,384 ± 96
IL-4	588 ± 30**	n.d.	135 ± 27^** ##	297 ± 19**
IL-5	453 ± 112*	8 ± 4	61 ± 21	115 ± 9
IL-10	1,348 ± 163**	27,251 ± 2,594	2,550 ± 253**	2,773 ± 62**
IL-12(p70)	508 ± 64**	10,778 ± 1,029	985 ± 100**	1,073 ± 25**
TNF-α	6,259 ± 505**	52,511 ± 1,123	23,282 ± 3,927^** ##	5,696 ± 971**
GM-CSF	125 ± 75**	12,070 ± 1,196	679 ± 117**	782 ± 29**

n.d., not detected. **𝑃<0.01, *𝑃<0.05 ((−) versus Control, S. thermophilus ST28, or S. thermophilus ATCC 19258) ^##𝑃<0.01 (S. thermophilus ST28 versus S. thermophilus ATCC 19258).