Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes
Figure 1
Beat-to-beat fidelity of EC coupling in ventricular myocytes. (a) Average peak amplitude of action potential evoked (1 Hz) global Ca2+ transients (nM) from adult (closed circles) and neonatal (open circles) ventricular myocytes measured at 1 minute interval for five minutes and corresponding coefficient of variation among the adult and neonatal myocyte population. Dashed line represents average peak [Ca2+]i signal over 5 minutes. (b) Representative [Ca2+]i transient of adult and neonatal myocytes. (c) Representative [Ca2+]i signal variance of adult and neonatal ventricular myocytes and the distribution of peak amplitude [Ca2+]i variance (nM2) of adult ventricular myocytes in the presence and absence of the SR Ca2+ pump inhibitor thapsigargin (1 μM).
