Figure 1: Changes in the serum lipid levels of WHHLMI rabbits with age (a), and the distribution of cholesterol in lipoproteins (b). Data are represented as the mean ± standard error of the mean. The serum cholesterol levels at 12 months old were about 900 mg/dL. Excess LDL cholesterol is atherogenic and HDL has antiatherogenic function. In WHHL rabbits, LDL is accumulated in the plasma and HDL-cholesterol is low, less than 20 mg/dL. The serum cholesterol levels decrease gradually with aging.