Review Article
Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases
Table 2
Drug development using WHHL/WHHLMI rabbits.
| | Lipid-lowering effect | Lipid-lowering effect | Aorta | Coronary arteries |
| Cholesterol synthesis inhibitors | | | | Statins | O | X, O | O | Squalene synthesis inhibitor | O | O | O | Anion exchanger | O | O | | Statins + Anion exchanger | O | O | O | MTP inhibitor | O | | | ACAT inhibitor | X, O | X, O | X, O | Antioxidants | | | | Probucol | O | O | | Vitamin E | X | X, O | | Colony stimulating factor | | | | MCSF | X, O | O | | GMCSF | X, O | O | | Apo E | X, O | O | | Fibrate | X | | | Fish oils, ommega-3 fatty acids | X, O | X, O | | Thiazolidinedione | X | Δ | Δ | Thiazolidinedione + statin | O | O | O | Antihypertensive | | | | ACE inhibitor | X | O | | AT-II receptor antagonists | X | O | | Calcium antagonists | X | X | | Beta-blockers | X | X | | Gene therapy | O | | |
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O: effective; Δ: partly effective; X: no effect. Modified from Shiomi and Ito [8].
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