Dysfunction of Lacrimal and Salivary Glands in Sjögren's Syndrome: Nonimmunologic Injury in Preinflammatory Phase and Mouse Model
Figure 2
Dysfunction of renal function due to glomerulonephritis may precede glandular dysfunction. Glomerulonephritis in different ages of female B/WF1 mice. Slight increase of mesangial cells (a), diffuse thickening of basement membranes with segmental proliferation of mesangial cells (b), and sclerosing change (c) in glomeruli are visible. On the other hand, relatively normal structure in submandibular gland is seen (d), but at this time dysfunction of glands is reported [50]. Focal lymphoid cell infiltration (e), and dense infiltration (f) are visible. Samples were obtained survived mice (a, b, d, and e), whereas those were from dead mice (c and f). HE : (a–d). Azan: (e) and (f).
