Inflammatory Cytokines in Systemic Lupus Erythematosus

Figure 2

Model of gp130 transsignaling. IL-6 signaling occurs by binding its membrane bound receptor (IL-6R) in target cells and subsequent dimerization of gp130 (Figure on the left). Cells which do not express IL-6R can also be susceptible to IL-6 via soluble IL-6 receptors that dimerize with membrane bound gp130 (Figure on the right).