Research Article
Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin
Table 2
Estimates of structural content of WT and mutant tropomyosins.
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Estimates of structural content for each of the five recombinant Tm’s were obtained from analyses of the individual CD spectra that were averaged for Figure 4. α-helical content was estimated from [θ]222 (Methods). Content of α-helix, β-sheet, and unordered structure was obtained using CDPro software (Methods). Values are mean ± S.D. ( spectra); note that, for CDPro estimates, S.D. is the mean of S.D. values from CDPro. |