IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy

Figure 3

IgG responses to specific prostate-associated antigens are detectable several months after initiation of treatment with ADT or a PAP vaccine. Immunoblot analysis was performed with the same panel of antigens using sera from individual subjects for whom sera was available 12 months after beginning treatment with ADT (24 of the original 34) or the PAP vaccine (19 of the original 21). The heatmap similarly shows gain of response pretreatment to 12 months posttreatment (light green), loss of response following treatment (black), or no change in response (dark green) for all subjects (in rows) and all antigens (in columns).