Research Article

IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy

Table 2

Estimate of PSA decline given biomarker evidence. Inference table describing estimates of the posterior distribution of PSA decline (target) representing estimates of likelihood of increase (0), decrease (1), or unknown (MISSING). For example, the most common case involves no change in any of the independent features (biomarkers), occurs 66.7% and results in a 64.1% posterior probability of PSA increase. The case representing an increase in IgG responses to BAC RP11-321G3, a decrease in IgG response to chromosome 1 gene contig and no change in IgG response to RP11-738B7 DNA on chromosome 7 occurs 1.1% of the time and results in a 6.9% posterior estimate of PSA increase.

Probability of caseDriversTarget
BAC RP11-321G3 CHANGEChromosome 1 gene contig CHANGE1RP11-738B7 DNA on chromosome 7 CHANGEPSA Decline

0.01.0MISSING

0.235%0.0−1.0−1.028.614.357.1
0.168%1.0−1.0−1.040.020.040.0
0.638%0.00.0−1.055.66.537.9
0.517%1.00.0−1.068.68.023.4
0.423%0.01.0−1.018.76.375.0
0.264%1.01.0−1.030.010.060.0
10.727%0.0−1.00.036.213.250.6
1.172%1.0−1.00.06.948.344.8
66.744%0.00.00.064.15.430.5
4.311%1.00.00.020.733.645.7
11.448%0.01.00.024.86.069.2
1.101%1.01.00.05.425.069.6
0.235%0.0−1.01.028.614.357.1
0.168%1.0−1.01.040.020.040.0
0.638%0.00.01.055.66.537.9
0.517%1.00.01.068.68.023.4
0.423%0.01.01.018.76.375.0
0.264%1.01.01.030.010.060.0