Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport

Figure 1

Effects of ketamine on alveolar fluid clearance in isolated human lungs. (a) Lungs were treated with 5% bovine serum albumin dissolved in physiologic saline solution in the absence of drugs (control), in the presence of amiloride (1 mM), ketamine (100 μM), and both (Keta + Amil). %AFC₆₀ represents the AFC percentage after 60 min. (b) Amiloride-sensitive (AS) AFC. Average AFC values are presented as the mean ± SEM, one-way ANOVA. *𝑃<0.05, **𝑃<0.01. 𝑛=5-6.

(a)

(b)