One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor

Figure 3

DNA-binding independent mechanisms. Mechanisms of p53-dependent repression independent of DNA-binding of p53. We classified these mechanisms roughly into two groups: one comprising interaction with other transcription cofactors (panel I), the second covering interaction of p53 with the basal transcription machinery (panel II). p53 has been shown to interact with TBP, TFIIA, TFIIB and/or diverse TAFs.