Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells: In Vitro and In Vivo Studies

Table 1

Selected ATSC-specific upregulated genes involved in neurospecific functions (𝑃<0.01).

Gene symbol	Gene bank	Gene name	Neurospecific functions				Process	References
			protection	development	trophism	metabolism
SLC1A1	NM_004170.5	Solute carrier family 1, member 1	+				Protection against glutamate neurotoxicity	[18]
CDH2	NM_001792.3	Cadherin 2, type 1, N-cadherin (neuronal)		+			Pre-to-postsynaptic adhesion neuronal migration Axonogenesis synapse assembly	[19]
CELF2	NM_001025077.2	CUG triplet repeat, RNA binding protein 2	+	+			Motor neuron survival splicing control during development	[7]
VLDLR	NM_003383.3	Very low density lipoprotein receptor	+	+		+	Protection against hypoxia and glucose starvation Nervous system development lipid uptake in neurons and astrocytes	[20]
NRP1	NM_003873	Neuropilin 1	+	+	+		Cell survival axon guidance Migration and invasion	[15]
NGFB	NM_002506.2	Nerve growth factor, beta polypeptide		+			Neuron differentiation nerve growth	[9]
ENC1	NM_003633.2	Ectodermal-neural cortex	+	+			Anti-apoptotic nervous system development	[21]
GCH1	NM_000161.2	GTP cyclohydrolase 1	+		+		Protection from brain damaging events secreted by astrocyte	[14]
FGF2	NG_012449.1	Fibroblast growth factor 2		+	+		Neurogenesis migration	[22]
NDN	NM_002487.2	Necdin homolog (mouse)	+	+			Protects neuron from oxidant stress Neuron development glial cell migration	[23]
PRPS1	NM_002764.3	Phosphoribosyl pyrophosphate synthetase 1		+		+	Purine synthesis nervous system development	[24, 25]
PGAM1	NM_002629.2	Phosphoglycerate mutase 1 (brain)	+			+	Regulation of energy metabolism neuroprotection against Aß-toxicity	[26]