Morphological and Molecular Alterations in 1,2 Dimethylhydrazine and Azoxymethane Induced Colon Carcinogenesis in Rats
Table 1
Nomenclature of colorectal lesions according to their morphological appearance on whole mount colon (low magnification) or according to their histological characteristics identified in embedded and stained colon sections under a high-magnification microscope.
Morphological description
Histological description
Tumour
Adenomas:
(i) polypoid
(i) low-grade dysplasia
(ii) nonpolypoid
(ii) high-grade dysplasia
Adenocarcinomas:
(i) well, moderate, and poorly differentiated adenocarcinomas
(ii) mucinous adenocarcinomas
(iii) signet-ring cell adenocarcinomas
(iv) solid or undifferentiated carcinomas
ACF (methylene blue)
Intraepithelial lesions:
(i) “dysplastic”
(i) hyperplastic
(ii) dark
(ii) dysplastic/intraepithelial neoplasia/microadenoma/carcinoma in situ
