MicroRNA Gene Dosage Alterations and Drug Response in Lung Cancer

Figure 4

Heatmap visualization of the miRNA expression of the 254 miRNAs (represented by 292 unique probes) that passed expression filtering criteria for the 21 most sensitive (yellow bar, low IC₅₀) and 21 most resistant (blue bar, high IC₅₀) to drug HKI-272. In total, 30 miRNAs were found to be significantly differentially expressed between the most sensitive and resistant lung cancer cell lines (LCCLs, orange bar). For this visualization, since a value of 4 represented no expression, all expression values were subtracted by 4 such that baseline expression would be shown as 0 (black).