MicroRNA Gene Dosage Alterations and Drug Response in Lung Cancer

Table 4

Differentially expressed mRNA targets for the four identified miRNAs.

miRNA	10b	328	193b	193b	628
Drug	MG-132 (26S Proteasome inhibitor)	Geldanamycin (HSP90 inhibitor)	AZ628 (RAF inhibitor)	MK-0457 (Aurora kinase inhibitor)	PF-2341066 (MET, ALK inhibitor)
Targets	SMARCC1	SLC16A1	PHF15	EIF2S1	DCTD
	MKRN2	ANGEL1	RPP30	ARIH2	NUP188
	CMTM6	UBR5	RRP1B	TMEM231	ELAC1
	CSDE1	SEMA3C	EIF4B	GABBR1	DACT1
	MAP4	MEIS2	WDR48	IKZF1	CYP7B1
	MYO10	TRIM32	PTPN21	FKTN	RPA4
	NKTR	GM2A	CLEC2D	GPATCH8	GAR1
	RYBP	EIF2S1	MRPS16	EZH1	UCKL1
	ZNF532	RAC2	NUDT15	OLFML2A	IL7
	SENP5	OLFML2A	NECAP2	PSME3	ABCE1
	CBL	HIP1		AGTPBP1	CASP3
	WHSC1	PRKD3		NMT2	WBP4
	FOXJ2	VDR		ADARB1	KLF9
	APOLD1	YME1L1		GREB1	ACTN2
	PEA15	TP63		SMC5	GPM6A
	RAD1	TFAP2C		CCDC28A	LSM12
	CDC6	CHP2		RNMT	PRKCA
	UBE2K	STK24		C15orf29	ADAT1
	BNIP2	GPR126		RRP1B	PBRM1
	PARD6B	SERTAD2		AGPAT4	SP2
	FGD6	DSC2		UBA52	TRAIP
	MMP14	PTGIS		GOSR1	MAGOHB
	OLFML2A	RAB22A		PRKD3
	GNL3L	FBXW2		SYF2
	CTDSPL	HS2ST1		SSX2IP
	MME	RPP30		ANKH
	PPFIBP1	SLC16A3		ZBTB39
	M6PR	MAN1A2		KBTBD11
	KPNA6	TGIF2		SEC16A
	RMI1	CLEC2D		PHC3
	RBM15B			ZNF510
	SS18L2			RTF1
				CYLD
				WDR48
				BTRC
				CCNT2
				RAB36