Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs: A QSPR Approach

Table 3

Pharmacokinetic parameters derived for all fluoroquinolones using in vivo cassette dosing approach in rabbits.

Fluoroquinolones	Cmax ± SD (μg/mL)	Tmax (min)	AUC (μg⋅hr/mL)	logPC (30 min)	logPC (240 min)
Norfloxacin	0.456 ± 0.059	60 min	2.854	−5.051	−6.382
Ciprofloxacin HCl	0.146 ± 0.084	60 min	0.507	−5.806	−7.089
Lomefloxacin HCl	0.266 ± 0.046	60 min	0.833	−5.519	−6.859
Ofloxacin	0.597 ± 0.736	60 min	0.930	−5.284	−6.723
Levofloxacin	0.147 ± 0.053	60 min	0.311	−5.678	−7.225
Sparfloxacin	1.151 ± 0.514	30 min	1.770	−4.753	−6.396
Pefloxacin mesylate	4.103 ± 1.399	60 min	7.225	−4.075	−5.778
Gatifloxacin	0.682 ± 0.904	30 min	1.179	−5.006	−6.628
Moxifloxacin	0.594 ± 0.294	30 min	1.045	−5.022	−6.664