Table 2: Animal models of plaque rupture and plaque associated thrombosis.


39–54-month-old pigs with inherited hyper=LDL cholesterolemia.ApoE−/− mice after squeezing the aorta supplemented between forceps.

42–54-week old ApoE−/− mice.Hypercholesterolemic rabbits subjected to balloon injury.

Dahl salt-sensitive hypertensive transgenic rats for human cholesteryl ester transfer protein.Atherosclerotic ApoE−/− mice subjected to photochemical injury.

Intraperitoneal injection of Russell’s viper venom in New Zealand White rabbits intermittently fed with high cholesterol diet.

Intraperitoneal injection of Russel’s viper venom in Watanabe heritable hyperlipidemic rabbits, in combination with the administration of serotonin or angiotensin II.