BioMed Research International / 2011 / Article / Tab 3

Review Article

Animal Models of Cardiovascular Diseases

Table 3

Current procedures for inducing AAA in animals.

SpeciesAAA models

MurineCalcium Chloride [56].
Elastase infusion [57].
Angiotensin-II-infused AAA: used in hyperlipidemic (ApoE−/− or LDLR−/−) male mice or in wild-type C57BL/6 mice in conjunction with repeated administration of neutralizing TGF-β antibodies [50].
Decellularized xenografts: grafting of abdominal aortic extracellular matrix from one species to a compatible recipient of a different species [58].
Spontaneous [59].

RabbitElastase-induced AAA: similar to the murine model [60], also applicable to the carotid artery [61].
Calcium chloride [62].

PigSurgical model: dilatation of the infrarenal aorta with an angioplasty balloon followed by infusion of pancreatic porcine elastase [63].

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.