Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver

Figure 1

Effect of orange juice (OJ) on the plasma concentration of pravastatin (PRV) in Sprague-Dawley rats. OJ was administered orally 8 times (1st day) and 5 times (2nd day) at hourly intervals. The starting dose of OJ was 5 mL/kg, and each consecutive dose was 2.5 mL/kg. Tap water instead of OJ was given to the control group. A single dose of PRV at 100 mg/kg p.o. was administered 1 h after the last ingestion of OJ or tap water. PRV levels were measured using the HPLC method described in Section 2.