Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver
Figure 5
Effect of hesperidin on Mrp2 protein levels in both the liver (a) and small intestine (b) in rats. Hesperidin instead of OJ was given to 8-week-old male Sprague-Dawley rats according to the same schedule and volume as in the OJ study. Tap water was also given as a control. The hesperidin solution was prepared at a concentration of 79 mg per 100 mL of tap water. The small intestine and liver were removed 1 h after the last ingestion of hesperidin. Western blot analysis was performed using the same methods as in the in vitro OJ study.
