Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver

Table 1

Effect of orange juice on the pharmacokinetic parameters of single-orally administrated pravastatin on rats.

Parameter	Control	Orange Juice	Ratio
	(𝑛=6)	(𝑛=6)	(OJ/Cont)
𝐶max (ng/mL)	120.8 ± 17.2	161.4 ± 26.4*	1.34
𝑇max (min)	48.0 ± 12.5	50.0 ± 12.2	1.04
𝑡1/2 (min)	75.5 ± 18.4	138.8 ± 58.5*	1.84
CL/f (L/hr)	105.0 ± 22.8	49.0 ± 17.4**	0.47
AUC (ng⋅hr/mL)	207.1 ± 21.4	291.3 ± 78.0*	1.41

The data are expressed as the mean ± S.D.
* 𝑃<.05 and **𝑃<.01, significantly different from control.