Computational Vaccinology: An Important Strategy to Discover New Potential S. mansoni Vaccine Candidates

Table 1

S. mansoni tegument surface exposed proteins evaluated as vaccine targets.

Candidate	Vaccine type	Immunologic response	Humoral response	Eggs reduction	Worms reduction	Bioinformatic tool	Ref.
Sm-p80	DNA vaccine (PcDNA)	Th1^a,b	IgG, IgG2a and IgG2b	84%	59%	ND	[31]
TSP-2	Recombinant protein	ND	IgG, IgG1 and IgG2a	64% (liver) 65% (feces)	57%	BLAST	[19, 32]
Sm29	Recombinant protein	Th1^a,b	IgG, IgG1 and IgG2a anti-Sm29	60% (intestinal eggs)	51%	BLAST, InterPro Scan, SignalP 3.0, SignalP Neural, NetNGlyc 1.0, WolfPSORT, SOSUI, Compute pI/Mw tool, GOR IV.	[20, 21]
ECL (200 Kda protein)	DNA vaccine	ND	IgG, IgG1 > IgG2a	ND	38.1%	ND	[33]
Sm 25	Peptide vaccine	ND	IgG	No significative difference with control group	No significative difference with control group	ND	[34, 35]

ND: not determined. Sm25 were tested in mice and rats, all the others antigens were tested in mice.