Loss of the NHE2 Na⁺/H⁺ Exchanger in Mice Results in Dilation of Folliculo-Stellate Cell Canaliculi

Figure 1

Cystic changes develop with age in the pars distalis of Nhe2^-/- mice. H&E stained sections of Nhe2^-/- pituitaries were examined at the following ages: (a) 5 weeks, (b) 8 weeks, and (c) 10 weeks. Note the presence of dilated canaliculi (open spaces) at 8 weeks and 10 weeks. No cyst-like dilatations of the canaliculi were seen in the WT mice at 10 weeks (d) or earlier ages (not shown). Bar: 20 μm.

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