Table 1: Classification of HDACs and selected HDACIs.

HDAC ClassHDAC isoformsLocalization of HDACSpecific HDAC inhibitorsNonspecific HDAC inhibitorsReferences

Class IHDAC1NucleusMS-275, FK-228TSA[9, 16]
(Zn -dependent)HDAC2NucleusFK-228, apicidinSAHA
HDAC3NucleusMS-275, ApicidinButyrate
HDAC8NucleusValproic acid

Class IIaHDAC4Nuc/CytTSA
SAHA
Butyrate
Valproic acid
[9, 16]
(Zn -dependent)HDAC5Nuc/Cyt
HDAC7Nuc/Cyt
HDAC9Nuc/Cyt

Class IIbHDAC6Mainly CytTubacinTSA
SAHA
[16]
(Zn -dependent)HDAC10Mainly Cyt

Class IIISIRT1Nuc/CytSuraminNicotinamide[9, 17]
(NAD -dependent)SIRT2Nuc/CytSuramin, AGK2
SIRT3Nuc/Mitoch
SIRT4Mitochondria
SIRT5MitochondriaSuramin
SIRT6Nucleus
SIRT7Nucleus

Class IV (Zn -dependent)HDAC11Nuc/CytTSA
SAHA
[16]