Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock

Table 1

Classification of HDACs and selected HDACIs.

HDAC Class	HDAC isoforms	Localization of HDAC	Specific HDAC inhibitors	Nonspecific HDAC inhibitors	References
Class I	HDAC1	Nucleus	MS-275, FK-228	TSA	[9, 16]
(Zn++-dependent)	HDAC2	Nucleus	FK-228, apicidin	SAHA
	HDAC3	Nucleus	MS-275, Apicidin	Butyrate
	HDAC8	Nucleus		Valproic acid
Class IIa	HDAC4	Nuc/Cyt		TSA; SAHA; Butyrate; Valproic acid	[9, 16]
(Zn++-dependent)	HDAC5	Nuc/Cyt
	HDAC7	Nuc/Cyt
	HDAC9	Nuc/Cyt
Class IIb	HDAC6	Mainly Cyt	Tubacin	TSA; SAHA	[16]
(Zn++-dependent)	HDAC10	Mainly Cyt
Class III	SIRT1	Nuc/Cyt	Suramin	Nicotinamide	[9, 17]
(NAD+-dependent)	SIRT2	Nuc/Cyt	Suramin, AGK2
	SIRT3	Nuc/Mitoch∗
	SIRT4	Mitochondria
	SIRT5	Mitochondria	Suramin
	SIRT6	Nucleus
	SIRT7	Nucleus
Class IV (Zn++-dependent)	HDAC11	Nuc/Cyt		TSA; SAHA	[16]