Review Article
Contributions of Cytogenetics and Molecular Cytogenetics to the Diagnosis of Adipocytic Tumors
Table 1
Chromosomal aberrations and associated molecular events in adipocytic tumors.
| | Tumor type | Chromosomal aberration | Molecular event |
| | Benign | | | | Lipoma | t(3;12)(q27-28;q13–15) | HMGA2-LPP | | t(9;12)(p22;q13–15) | HMGA2-NFIB | | t(2;12)(q37;q13–15) | HMGA2-CXCR7 | | t(5;12)(q32-33;q13–15) | HMGA2-EBF1 | | t(12;13)(q13–15;q12) | HMGA2-LHFP | | 6p21–23 rearrangement | HMGA1 rearrangement | | 13q deletion | Not known | | Chondroid lipoma | t(11;16)(q13;p13) | C11of95-MKL2 | | Spindle cell/pleomorphic lipoma | 13q and/or 16q deletions | Not known | | Hibernoma | 11q13 rearrangement | MEN1, PPP1A deletion | | Lipoblastoma | 8q11–13 rearrangement | PLAG1 rearrangement |
| | Intermediate (locally aggressive) | | | | Atypical lipomatous tumor/ | Ring/giant marker chromosome | MDM2, CDK4, CPM, | | well differentiated liposarcoma | (12q13–15 amplification) | HMGA2 amplification |
| | Malignant | | | | Dedifferentiated liposarcoma | Ring/giant marker chromosome* | MDM2, CDK4, CPM, | | (12q13–15 amplification) | HMGA2 amplification | | Myxoid/round cell liposarcoma | t(12;16)(q13;p11) | FUS-DDIT3 | | t(12;22)(q13;q12) | EWSR1-DDIT3 | | Pleomorphic liposarcoma | Complex karyotype | Not known |
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Dedifferentiated liposarcoma may contain complex aberrations in addition to ring or giant marker chromosomes.
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