Early Detection of Tumor Response by FLT/MicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model

Table 1

Biodistribution of ¹⁸F-FDG/¹⁸F-FLT after i.v. injection.

	FDG			FLT
Organ	Day 4	Day 8	Day 9	Day 4	Day 8	Day 9
Whole blood	0.39±0.01	0.42±0.04	0.46±0.03	1.04±0.19	0.76±0.03	1.24±0.20
Brain	6.93±0.49	6.70±0.60	5.44±0.52	0.21±0.03	0.15±0.01	0.22±0.03
Skin	1.11±0.06	1.12±0.10	0.79±0.17	0.66±0.13	0.55±0.04	0.74±0.12
Muscle	2.62±0.41	2.27±0.27	2.78±0.64	0.75±0.22	0.68±0.08	1.01±0.21
Bone	1.71±0.23	1.66±0.23	1.93±0.32	0.93±0.08	0.93±0.15	0.50±0.06
Red marrow	11.89±6.11	8.67±0.97	5.54±1.00	1.77±0.65	3.01±1.08	0.98±0.30
Heart	15.55±1.33	16.94±1.95	20.95±2.34	0.80±0.15	0.67±0.06	0.96±0.18
Lung	2.26±0.11	2.46±0.21	2.40±0.22	0.81±0.15	0.64±0.03	0.95±0.13
Testis	2.44±0.10	2.77±0.20	2.23±0.18	1.49±0.14	1.25±0.09	1.71±0.19
Spleen	2.71±0.31	3.08±0.18	3.38±0.16	1.79±0.29	2.26±0.23	1.23±0.21
Pancreas	1.73±0.09	1.83±0.13	2.14±0.11	0.98±0.19	0.76±0.04	1.18±0.17
Kidney	2.01±0.24	1.33±0.15	1.90±0.15	2.27±0.29	2.46±0.27	3.07±0.62
Adrenals	3.87±0.67	4.55±0.43	4.32±0.59	1.44±0.22	2.48±0.62	1.69±0.44
Liver	0.80±0.03	0.96±0.05	0.93±0.05	1.03±0.16	0.80±0.05	1.17±0.18
Bladder	2.63±0.56	2.13±0.32	2.75±0.86	3.42±0.33	4.84±0.77	3.81±0.55
Stomach	3.25±0.27	5.07±0.47	4.54±0.49	0.87±0.13	0.81±0.05	1.06±0.22
Small intestine	3.04±0.28	5.33±1.59	3.86±0.70	3.19±0.73	3.28±0.71	2.31±0.25
Large intestine	7.11±0.61	7.81±0.85	7.29±0.73	1.54±0.22	1.76±0.40	2.27±0.31
10^5 tumor	4.67±1.16	5.30±0.62	4.32±0.56	1.16±0.40	2.70±0.34	2.12±0.24
10^6 tumor	9.03±3.58	4.83±0.61	3.92±0.46	2.38±0.37	3.27±0.13	2.09±0.20
10^5 T/M	1.58	2.62	1.98	1.65	4.19*	2.38
10^6 T/M	3.49	2.40	1.81	4.02	5.13**	2.24

Data were expressed as %ID/g (Mean ± SEM, n = 5) (*: P < 0.05, significantly different at day 8 and day 9 in 10⁵ tumor cell inoculation; **: P < 0.05, significantly different at day 8 and day 9 in 10⁶ tumor cell inoculation).