Comparative Study of Human Hematopoietic Cell Engraftment into Balb/c and C57BL/6 Strain of Rag-2/Jak3 Double-Deficient Mice

Figure 1

Lack of mature lymphocytes and NK cells in both Balb/c and C57/BL6 background Rag-2^−/−Jak3^−/− mice. Spleen cells from C57/BL6 wild-type mice, Rag-2^−/−Jak3^−/− mice and Balb/c wild-type mice, and Rag-2^−/−Jak3^−/− mice, were stained with DX5-FITC (pan NK marker), CD122 (IL-2Rβ), CD19-APC, and CD3-PE/Cy7. No T and B lymphocytes or NK cells were observed in the spleen of Rag-2^−/−Jak3^−/− mice.