Comparative Study of Human Hematopoietic Cell Engraftment into Balb/c and C57BL/6 Strain of Rag-2/Jak3 Double-Deficient Mice
Figure 2
Balb/c Rag-2−/−Jak3−/− mice support human hematopoietic stem cell engraftment more efficiently than C57/BL6 Rag-2−/−Jak3−/− mice. Cord blood-derived CD34+ cells ( cells/ mouse) were transplanted into irradiated newborn mice intrahepatically. Peripheral blood of CD34-transplanted recipients was obtained 12 weeks after transplantation, and human and murine chimerism was assessed by flow cytometry.
