Rodent Preclinical Models for Developing Novel Antiarthritic Molecules: Comparative Biology and Preferred Methods for Evaluating Efficacy
Figure 4
Bone mineral density (BMD) of the tibiotarsal region (hock (or “ankle”)) by dual X-ray absorptiometry (DXA) is a rapid means of evaluating bone integrity in arthritic rodent hind paws. Relative to a nonarthritic control (a), BMD is greatly reduced in multiple bones (bordered by the yellow rectangle) of a young adult, male Lewis rat with the mycobacterial variant of adjuvant-induced arthritis (AIA-Myc). These panels are reproduced from [155] with the permission of the American College of Rheumatology.
