Research Article
Variability in Estrogen-Metabolizing Genes and Their Association
with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women
Table 2
The genotype frequencies of the CYP17, CYP1B1, CYP1A1, and COMT gene variants in breast cancer patients and controls, and after menopause.
| Genotype | Breast cancer patients () | Controls () | OR (95% CI) | P value | Number | Frequency | Number | Frequency |
| CYP17 | | | | | | | Premenopause | | | | | | | TT | 16 | 0.25 | 22 | 0.35 | 1.0 (reference) | .81 | TC+CC | 14 | 0.23 | 17 | 0.27 | 1.1 (0.4-2.9) | | Postmenopause | | | | | | | TT | 11 | 0.18 | 16 | 0.26 | 1.0 (reference) | .01 | TC+CC | 21 | 0.34 | 7 | 0.12 | 4.3 (1.3–13.7) | | CYP1B1 | | | | | | | Premenopause | | | | | | | Val/Val | 6 | 0.1 | 15 | 0.24 | 1.0 (reference) | .11 | Val/Leu+Leu/Leu | 24 | 0.39 | 24 | 0.39 | 2.5 (0.8–7.5) | | Postmenopause | | | | | | | Val/Val | 11 | 0.18 | 6 | 0.1 | 1.0 (reference) | .56 | Val/Leu+Leu/Leu | 21 | 0.33 | 17 | 0.27 | 0.6 (0.2–2.1) | | CYP1A1 | | | | | | | Premenopause | | | | | | | TT | 16 | 0.25 | 36 | 0.58 | 1.0 (reference) | .0004 | TC+CC | 14 | 0.23 | 3 | 0.05 | 10.5 (2.6–41.7) | | Postmenopause | | | | | | | TT | 24 | 0.39 | 17 | 0.27 | 1.0 (reference) | 1.0 | TC+CC | 8 | 0.13 | 6 | 0.1 | 0.9 (0.2–3.2) | | COMT | | | | | | | Premenopause | | | | | | | Val/Val | 10 | 0.16 | 24 | 0.38 | 1.0 (reference) | .02 | Val/Met+Met/Met | 20 | 0.32 | 15 | 0.24 | 3.2 (1.1–8.6) | | Postmenopause | | | | | | | Val/Val | 11 | 0.18 | 12 | 0.2 | 1.0 (reference) | .2 | Val/Met+Met/Met | 21 | 0.34 | 11 | 0.18 | 2.0 (0.6–6.2) | |
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