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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 589414, 8 pages
http://dx.doi.org/10.1155/2011/589414
Review Article

Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases

1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China
2Department of Biomedical Science, College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA
3Department of Neurology, Newborn Brain Research Institute, University of California, San Francisco, CA 94143, USA

Received 21 July 2011; Accepted 31 August 2011

Academic Editor: J.-P. Jin

Copyright © 2011 Gang Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity in Drosophila and gastrulation movements and cardiogenesis in vertebrates, has been shown to play multiple roles during cardiac differentiation and development. The disrupted function of PCP signaling is connected to some CHDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of CHD.