Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer?

<table>Synaptophysin staining in prostate cancer cells treated with VPA <i>in vitro. </i>(a): Representative images of synaptophysin staining for cell pellet sections from control and VPA-treated groups: LNCaP, C4-2, PC-3, and DU-145 (Scanned at 20X magnification using the APERIO imaging system). (b) Weighted scoring of IHC staining for synaptophysin (<svg height="13.75" id="M18" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 7.7375002 13.75" width="7.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,5.525)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5
q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g>
</svg> indicates <i>P</i> &lt; .05).</table>

BioMed Research International

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Figure 2

Figure 2: Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer? 