Figure 3: Morris water maze performed at 4-5 months of age of PS2Tg2576 mice. (a) The escape latency of 4-5-month-old mice in the hidden platform trial. Training trials were repeated for 4 days (1 minute/trial, 4 trials/day). The graph shows representative swimming paths of individual mice on day 4 of the training phase. (b) The number of crossings of the removed-platform area in the probe test. A probe trial, in which the platform was removed, was performed for 2 minutes on the day after the training trials had finished. (c) Percentage of time spent in the target quadrant during the probe trial. (d) Representative swimming paths of individual mice during the probe test in the training phase. The arrowhead represents the entry point. Values represent the mean ± s.e.m. ( , female and male mixture). Statistical significance was assessed using the unpaired -test (c, d): * compared with the wild-type mice at the same age; # compared with the Tg2576 mice at the same age.