Histological examination of adult Soleus fibers: fibers presenting structural damage were absent in WT, rare in CASQ1-null, but quite frequent in dCASQ-null. We classified abnormal fibers in two main classes: (a) fibers presenting large areas loosing cross striation, or unstructured cores
, but no contractures (see Figure 4
(f)); (b) fibers containing (also) contracture cores
(see Figure 4
(e), asterisk). (c) About 35% of Soleus fibers from dCASQ-null mice present severe structural alterations.