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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 685870, 4 pages
http://dx.doi.org/10.1155/2011/685870
Research Article

Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis

1Clinical Institute of Occupational Medicine, University Medical Center, Poljanski Nasip 58, 1000 Ljubljana, Slovenia
2Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia

Received 27 September 2010; Revised 10 March 2011; Accepted 23 March 2011

Academic Editor: Celina Janion

Copyright © 2011 Alenka Franko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)n polymorphism is associated with an increased asbestosis risk in exposed workers. The study cohort consisted of 262 cases with asbestosis and 265 controls with no asbestos-related disease. For each subject the cumulative asbestos exposure data were available. The number of CCTTT repeats was determined following PCR amplification of the iNOS promoter region. Logistic regression was performed to estimate asbestosis risk. The OR of asbestosis was 1.20 (95%  CI = 0.85–1.69) for the LL genotype compared to the combined SL and SS genotypes and 1.26 (95%   CI = 0.86–1.85) for the LL genotype compared to the SL genotype. The results of this study are borderline significant and suggest a possible role of iNOS (CCTTT)n polymorphism in the risk of asbestosis; however, further studies are needed.