Figure 2: Cytokine concentrations in reach and support wrist joint (distal most radius, distal ulna, first row of carpal bones, and associated joint regions), tested using ELISA. Levels of (a) Interleukin (IL)-1α, (b) tumor necrosis factor (TNF)-α, (c) IL-10, (d) IL-1β, and (e) IL-6 are shown for NC (normal control), NC + IBU (normal controls receiving ibuprofen for 8 weeks), TR (trained controls), TR + IBU (trained controls receiving ibuprofen treatment in final 8 weeks), HRHF (rats performing high-repetition high-force task for 12 weeks), and HRHF + IBU (HRHF rats receiving ibuprofen treatment in final 8 weeks). Abbreviations: compared to NC, compared to NC + IBU, compared to TR; compared to TR + IBU; compared to HRHF + IBU; a = support limb is significantly different from reach limb, .